Despite making a late comeback attempt, the Minutemen fell to the Rainbow Warriors 46-40, dropping them to 2-10 on the season.
The Minutemen failed to score in the second half in Provo, allow 37 points over final two quarters.
The Minutemen were down just four points early in the third quarter, but could not keep momentum in their loss to the Trojans.
Minutemen coach Mark Whipple told reporters Tuesday that Huber suffered an ACL injury earlier this season.
Notebook: UMass football coach Mark Whipple not tipping hand in quarterback decision for Saturday’s game
After missing the entire second half against Florida International, inside linebacker Shane Huber is expected to be a game day decision against the Bulldogs.
After losing eight starters to graduation, the Minutemen’s defense has a much different look filled with underclassmen and junior-college transfers heading into the season.